The tTA atlas is an interactive resource providing access to brain wide histological images displaying the distribution patterns of promoter activity in different tetracycline transactivator (tTA) mouse models

Image collections:

Nop-tTA/tetO-lacZ-nls-GFP mice:

Animal 2849
(coronal sections)

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Animal 1952
(coronal sections)

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Animal 2877
(horizontal sections)
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tetO-lacZ-nls-GFP mouse - single transgenic control:

Animal 1950
(coronal sections)


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Overview

The atlas contains histological data documenting the activity of the Nop-tTA promoter in bigenic mice in which the Nop-tTA promoter regulates the expression of the LacZ reporter gene, encoding the histologically detectible marker β-galactosidase.

The Virtual Microscope tool allows users to navigate within and across section images.

The atlas is based on data from the following publication:

Yetman MJ, Lillehaug S, Bjaalie JG, Leergaard TB, Jankowsky JL (2015), Transgene expression in the Nop-TTA driver line is not inherently restricted to the entorhinal cortex. Brain Struct Funct DOI 10.1007/s00429-015-1040-9 (accepted manuscript)

Re-use of data from this repository is permitted provided reference is made to this publication. For methodological details, cfr. Yetman et al. (2015).