The tTA atlas is an interactive resource providing access to brain wide histological images displaying the distribution patterns of promoter activity in different tetracycline transactivator (tTA) mouse models

Credits

  • Animal breeding and immunohistochemistry:
    Michael J. Yetman, Joanna L. Jankowsky
  • Atlas development:
    Sveinung Lillehaug, Dmitri Darine, Gergely Scucs, Jan G. Bjaalie, Trygve B. Leergaard

 

Overview

The atlas contains histological data documenting the activity of the Nop-tTA promoter in bigenic mice in which the Nop-tTA promoter regulates the expression of the LacZ reporter gene, encoding the histologically detectible marker β-galactosidase.

The Virtual Microscope tool allows users to navigate within and across section images.

The atlas is based on data from the following publication:

Yetman MJ, Lillehaug S, Bjaalie JG, Leergaard TB, Jankowsky JL (2015), Transgene expression in the Nop-TTA driver line is not inherently restricted to the entorhinal cortex. Brain Struct Funct DOI 10.1007/s00429-015-1040-9 (accepted manuscript)

Re-use of data from this repository is permitted provided reference is made to this publication. For methodological details, cfr. Yetman et al. (2015).