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Disease models

Histological atlas systems for mapping spatial distribution of gene expression and immunolabelled proteins in transgenic neurodegenerative disease models

Open access projects

tTA / TetOff Atlas: Nop

Histological atlas documenting the activity of the Nop-tTA promoter in bigenic mice in which the Nop-tTA promoter regulates the expression of the LacZ reporter gene, encoding the histologically detectible marker β-galactosidase.

tTA / TetOFF Atlas: PrP, CamKII

 Histological atlas showing the spatial distribution of β-galactosidase expression produced by the Ca2+/calmodulin-dependent protein kinase II (CamKII) tetracycline-reponsive (TetOff) driver line in bigenic CamKII/LacZ mice, in comparison with the prion protein TetOff driver line>

TetOff Atlas I (PrP):

Histological atlas showing the spatial distribution of β-galactosidase expression produced by the prion protein (PrP) tetracycline-reponsive (TetOff) driver line in bigenic Prp/LacZ mice

Tg-ArcSwe atlas:

Histological atlas system showing the morphology and spatial distribution Aβx-40 immunolabeled histological section images in 12 month old bigenic mice carrying the Arctic and Swedish amyloid-β precursor protein mutation (tg-ArcSwe mice)

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